A Novel Photochemical Approach in the Synthesis of β-Lactams

β-Lactam antibiotics are amongst the most pivotal 和 ubiquitous antimicrobial compounds worldwide. 这些化合物, characterized by a defining chemical feature - the β-lactam ring – a four-membered ring containing an amidic function, represent adiverse 和 broad family of molecules. The persistent use of these compounds has fueled the emergence of resistant microorganisms, prompting intensive eForts to discover 和 synthesize new β-Lactam varieties with the goal of improving biological activity. 总计 laboratory synthesis of β-lactam antibiotics remains a formidable challenge due to the complex chirality 和 function of these molecules.

This research introduces a novel photochemical approach for the synthesis of β-lactam-containing molecules. Through extensive experimentation 和 optimization, this study increased yields from 27% to 71% in one model reaction, providing a successful 和 eFicient means of synthesis with considerable scale-up opportunity using a flow reactor. After experimentation with various photo-precursors, 有效隔离, 和 characterization of two β-Lactam-containing products serve as evidence to support the synthetic viability of this reaction, providing a new 和 eFicient means of β-Lactam synthesis.